論文

2004-

• Yokota,T.; Yu, Y.; Araseki, K.; Arai, T. Bis(imidazolidine)-Derived NCN Nickel-Pincer-Catalyzed Asymmetric Reactions. Org. Lett. 2024, 26, [DOI: /10.1021/acs.orglett.4c02773]
• Nagae, M.; Otsuka, H.; Sakai, T.; Furuse, A.; Bairi, P.; Wang, S.; Arai, T.; Kaneko, K. Nanoporosity changes of graphene oxide colloids on linkage-treatment with molecular linker and heating after the linkage-treating. Chem. Phys. Lett. 2024, 848, 141374. [DOI: /10.1016/j.cplett.2024.141374]
• Furusawa, I.; Suzuki, T.; Yu, Y.; Arai, T. Halogenation/Cyanation vs. Cyanation/Halogenation of Alkenes Using ICN and BrCN. Adv. Synth. Catal. 2023, 365 3247-3252. [DOI: /10.1002/adsc.202300458]
• Tajima, R.; Saito, T.; Arai, T. Asymmetric para-Selective aza-Friedel–Crafts Reaction of Phenols Catalyzed by Bulky PyBidine-Ni(OAc)2. ACS Catal. 2023, 13, 9495-9501. [DOI: /10.1021/acscatal.3c01961]
• Ogawa, K.; Chiba, T.; Nakamura, M.; Arai, J. ; Zhang, J.Q.; Ma, Y.J .; Qiang, N. ; Ao, J.J.; Yumita, S.; Ishino, T.; Kan, M.T.Y.S.; Iwanaga, T.; Nakagawa, M.; Fujiwara, K.; Sakuma, T.; Kanzaki, H.; Koroki, K.; Kusakabe, Y.; Kobayashi, K.; Kanogawa, N.; Kiyono, S.; Kondo, T.; Nakagawa, R.; Ogasawara, S.; Muroyama, R.; Nakamoto, S.; Kanda, T.; Maruyama, H.; Kato, J.; Matsumoto, S.; Arai, T.; Motohashi, S.; Kato, N. Successful Identification of a Novel Therapeutic Compound for Hepatocellular Carcinoma Through Screening of ADAM9 Inhibitors. Anticancer Res., 43, 2023, 1043-1052. [DOI: 10.21873/anticanres.16249]
• Yokota, T.; Masu, H.; Arai, T. Asymmetric Friedel–Crafts-Type Reaction of 2-Vinylindoles to N-Boc Imines Using a Chiral Imidazolidine-Containing NCN-Pincer Pd Catalyst. J. Org. Chem. 2023, 88, 7872-7881. [DOI: 10.1021/acs.joc.2c02911]
• Iida, K.; Suzuki, N.; Sasaki, A.; Ishida S.; Arai, T. Development of a novel light-up probe for detection of G-quadruplexes in stress granules. Sci. Rep. 2022, 12, 12892. [DOI: 10.1038/s41598-022-17230-y]
• Suzuki, T. K.; Yamanaka, M.; Arai, T. Intermolecular Catalytic Asymmetric Iodoetherification of Unfunctionalized Alkenes. Org. Lett. 2022, 24, 3872-3877. [DOI: 10.1021/acs.orglett.2c01490]
• Ogino, E.; Kuwano, S.; Arai, T. Chiral Aminomethylbinaphthol-Catalyzed Diastereo- and Enantioselective Epoxidation of Trisubstituted Acrylonitriles. Adv. Synth. Catal. 2022, 364, 1503-1506. [DOI: 10.1002/adsc.202200036]
• Kuwano, S.; Ogino, E.; Arai, T. Enantio- and diastereoselective double Mannich reaction of malononitrile with N-Boc imines using quinine-derived bifunctional organoiodine catalyst. Org. Biomol. Chem. 2021, 19, 6969-6973. [DOI: 10.1039/D1OB00796C]
• Nishida, Y.; Suzuki,T.; Takagi,Y.; Amma,E.; Tajima,R.; Kuwano,S.; Arai, T. A Hypervalent Cyclic Dibenzoiodolium Salt as a Halogen-Bond-Donor Catalyst for the [4+2] Cycloaddition of 2-Alkenylindoles. ChemPlusChem 2021, 86, 741-744. [DOI: 10.1002/cplu.202100089]
• Ogino, E.; Nakamura, A.; Kuwano, S.; Arai, T. Chiral C2-Symmetric Aminomethylbinaphthol as Synergistic Catalyst for Asymmetric Epoxidation of Alkylidenemalononitriles: Easy Access to Chiral Spirooxindoles. Org. Lett. 2021, 23, 1980-1985. [DOI: 10.1021/acs.orglett.0c04245]
• Ma, J.; Suzuki, T.; Kuwano, S.; Arai, T. Catalytic Asymmetric Chlorination of β-Ketoesters Using N-PFB-PyBidine-Zn(OAc)2. Catalysts, 2020, 10, 1177. [DOI: 10.3390/catal10101177]
• Nakamura, A.; Kuwano, S.; Sun, J.; Araseki, K.; Ogino, E.; Arai, T. Chiral Dinuclear Benzyliminobinaphthoxy‐Pd Catalyst for Asymmetric Mannich Reaction of Aldimines and Isatin‐derived Ketimines with Alkylmalononitriles. Adv. Synth. Catal. 2020, 362, 3105-3109. [DOI: 10.1002/adsc.202000447]
• Suzuki, T.; Kuwano, S.; Arai, T. Non‐bonding Electron Pair versus π‐Electrons in Solution Phase Halogen Bond Catalysis: Povarov Reaction of 2‐Vinylindoles and Imines. Adv. Synth. Catal. 2020, 362, 3208-3212. [DOI: 10.1002/adsc.202000494]
• Arai, T.; Horigane, K.; Suzuki, T. K.; Itoh, R.; Yamanaka, M. Catalytic Asymmetric Iodoesterification of Simple Alkenes. Angew. Chem. Int. Ed. 2020, 59, 12680-12683. [DOI: 10.1002/anie.202003886] selected in Hot Paper and Inside Back Cover [link]
• Kuwano, S.; Nishida, Y.; Suzuki, T.; Arai, T. Catalytic Asymmetric Mannich-Type Reaction of Malononitrile with N-Boc α-Ketiminoesters Using Chiral Organic Base Catalyst with Halogen Bond Donor Functionality. Adv. Synth. Catal. 2020, 362, 1674-1678. [DOI: 10.1002/adsc.202000092]
• Arai, T.; Araseki, K.; Kakino, J. Catalytic Asymmetric Aza-Friedel–Crafts-Type Reaction of Indoles with Isatin-Derived N-Cbz-Ketimines Using a Chiral Bis(Imidazolidine)-Containing NCN-Pincer Palladium Catalyst. Org. Lett. 2019, 21, 8572-8576. [DOI: 10.1021/acs.orglett.9b03148]
• Sato, R.; Tosaka, T.; Masu, H.; Arai, T. Catalytic Asymmetric Synthesis of Chiral Bis(indolyl)methanes Using Ts-PyBidine-Nickel Complex. J. Org. Chem. 2019, 84, 14248-14257. [DOI: 10.1021/acs.joc.9b02006]
• Kuwano, S.; Hosaka, Y.; Arai, T. Chiral Benzazaborole‐Catalyzed Regioselective Sulfonylation of Unprotected Carbohydrate Derivatives. Chem. Eur. J. 2019, 25, 12920-12923. [DOI: 10.1002/chem.201903443]
• Arai, T.; Iimori, Y.; Shirasugi, M.; Shinohara, R.; Takagi, Y.; Suzuki, T.; Ma, J.; Kuwano, S.; Masu. H. Bis(imidazolidine)pyridine-CoCl2: A Novel, Catalytically Active Neutral Complex for Asymmetric Michael Reaction of 1,3-Carbonyl Compounds with Nitroalkenes. Adv. Synth. Catal. 2019, 361, 3704-3711 [DOI: 10.1002/adsc.201900421]
• Kuwano, S.; Suzuki, T.; Yamanaka, M.; Tsutsumi, R.; Arai, T. Catalysis Based on C−I···π Halogen Bonds: Electrophilic Activation of 2-Alkenylindoles by Cationic Halogen-Bond-Donors for [4+2] Cycloadditions. Angew. Chem. Int. Ed. 2019, 58, 10220-10224 [DOI: 10.1002/anie.201903221]-Press Release [PDF]
• Arai, T.; Nakamura, A. Asymmetric Mannich Reaction of N-Boc Imines with Alkylmalononitriles Catalyzed by Dinuclear PhosphoiminoBINOL-Pd Complex. Synlett, 2019, 30, 1356-1360 [DOI: [DOI: 10.1055/s-0037-1611842].
• Iida, K.; Ishida, S.; Watanabe, T.; Arai, T. Disulfide Catalyzed Iodination of Electron-rich Aromatic Compounds. J. Org. Chem. 2019, 84, 7411-7417. [DOI: 10.1021/acs.joc.9b00769]
• Kuwano, S.; Hosaka, Y.; Arai, T. Chiral benzazaboroles as catalysts for enantioselective sulfonylation of cis-1,2-diols. Org. Biomol. Chem., 2019, 17, 4475–4482[DOI: 10.1039/c8ob03205j]
• Arai, T.; Horigane, K.; Watanabe, O.; Kakino, J.; Sugiyama, N.; Makino, H. Kamei, Y.; Yabe, S. Yamanaka, M. Association of Halogen Bonding and Hydrogen Bonding in Metal Acetate-catalyzed Asymmetric Halolactonization. iScience, 2019, 12, 280-292 [DOI: https://doi.org/10.1016/j.isci.2019.01.029]
• Kuwano, S.; Suzuki, T.; Hosaka,Y.; Arai, T. A chiral organic base catalyst with halogen-bonding-donor functionality: asymmetric Mannich reactions of malononitrile with N-Boc aldimines and ketimines. Chem. Comm. 2018, 54, 3847-3850. [DOI:10.1039/c8cc00865E]
• Arai, T.; Sato, K.; Nakamura, A.; Makino, H.; Masu, H. Dinuclear PhosphoiminoBINOL-Pd Container for Malononitrile: Catalytic Asymmetric Double Mannich Reaction for Chiral 1,3-Diamine Synthesis. Scientific Reports, 2018, 8, 837. [DOI:10.1038/s41598-018-19178-4]-Press Release [PDF]
• Kuwano, S.; Suzuki, T.; Arai, T. 2-iodoimidazolinium salt-catalyzed Friedel-Crafts reaction: synthesis of bis(indolyl)methane alkaloids. Heterocycles, 2018, 97, 163-169. [DOI:10.3987/COM-18-S(T)33]
• Arai, T. Chiral Bis(imidazoline)-containing NCN Pincer Metal Complexes for Cooperative Asymmetric Catalysis. J. Synth. Org. Chem, Japan. 2018, 76, 3-10. [DOI: 10.5059/yukigoseikyokaishi.76.3] (有機合成化学協会企業冠賞 日産化学・有機合成新反応/手法賞受賞論文)-ChemStation [link]
• Seira, N.; Yanagisawa, N.; Suganami, A.; Honda, T.; Wasai, M.; Regan, J. W.; Fukushima, K.; Yamaguchi, N.; Tamura, Y.; Arai, T.; Murayama, T.; Fujino, H. Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line. Biol. Pharm. Bull. 2017, 40, 1806-1812. [DOI: 10.1248/bpb.b17-00458]
• Arai, T.; Tosaka, T.; Kuwano,S. Catalytic Asymmetric Mannich Reaction of Isatin-derived N-Boc Imines with Malononitrile by Bis(imidazolidine)-derived Pincer Rh Complex. ChemistrySelect. 2017, 2, 7368–7371. [DOI: 10.1002/slct.201701444]
• Arai, T.; Tsuchida, T.; Miyazaki, T.; Awata, T. Catalytic Asymmetric Synthesis of Chiral 2-Vinylindole Scaffolds by Friedel–Crafts Reaction. Org. Lett. 2017, 19, 758-761. [DOI: 10.1021/acs.orglett.6b03584]
• Kuwano, S.; Masuda, T.; Yamaguchi, K.; Arai, T. N-Heterocyclic Carbene-Promoted [3+2] Cycloaddition of Allenyl Sulfone and Arylidenemalononitriles. Heterocycles 2017, 95, 232-242. [DOI: aa10.3987/COM-16-S(S)8]
• Arai, T.; Suzuki, T.; Inoue, T.; Kuwano, S. Chiral Bis(imidazolidine)iodobenzene (I-Bidine) Organocatalyst for Thiochromane Synthesis Using an Asymmetric Michael/Henry Reaction. Synlett 2017, 122-127. [DOI: 1055/s-0036-1588614].
• Arai, T.; Miyazaki, T.; Ogawa, H.; Masu, H. PyBidine-Ni(OAc)2-Catalyzed Michael/Aldol Reaction of Methyleneindolinones and Thiosalicylaldehydes for Stereochemically Divergent Thiochromanyl-spirooxindoles. Org. Lett. 2016, 18, 5824-5827 [DOI: 10.1021/acs.orglett.6b02783]- highlighted in SYNFACTS [jpg]
• Arai, T.; Kakino, J. Catalytic Asymmetric Synthesis of 3-Indolyl Methanamines Using Unprotected Indoles and N-Boc Imines under Basic Conditions. Angew. Chem. Int. Ed. 2016, 55, 15263–15267 [DOI: 10.1002/anie.201607679]- highlighted in SYNFACTS [jpg]
• Touge, T.; Arai T. Asymmetric Hydrogenation of Unprotected Indoles Catalyzed by η6-Arene/N-Me-sulfonyldiamine–Ru(II) Complexes. J. Am. Chem. Soc. 2016, 138, 11299-11305 [DOI: 10.1021/jacs.6b06295] (Press Release) (News Paper) - highlighted in SYNFACTS [jpg]
• Arai, T.; Tokumitsu, C.; Miyazaki, T.; Kuwano, S.; Awata A. Catalytic Asymmetric [3+2]-Cycloaddition for Stereodivergent Synthesis of Chiral Indolyl-pyrrolidines. Org. Biomol. Chem. 2016, 14, 1831-1839 [DOI: 10.1039/ c5ob02278a].
• Sato, T.; Miyazaki, T.; Arai, T. Synthesis of Highly Functionalized Chiral Benzopyrano[3,4-c]pyrrolidines Bearing Five Contiguous Stereogenic Centers J. Org. Chem. 2015, 80, 10346-10352. [DOI: 10.1021/acs.joc.5b01445].
• Arai, T.; Watanabe, O.; Yabe, S.; Yamanaka, M. Catalytic Asymmetric Iodocyclization of N-Tosyl Alkenamides using Aminoiminophenoxy Copper Carboxylate: A Concise Synthesis of Chiral 8-Oxa-6-Azabicyclo[3.2.1]octanes. Angew. Chem. Int. Ed. 2015, 54, 12767-12771. [DOI: 10.1002/anie.201505748]. - highlighted in SYNFACTS [jpg]
• Arai, T.; Kojima, T.; Watanabe, O.; Itoh, T.; Kanoh, H. Recyclable poly-Zn3(OAc)4-3,3'-bis(aminoimino)binaphthoxide catalyst for asymmetric iodolactonization. ChemCatChem. 2015, 7, 3234-3238. [DOI: 10.1002/cctc.201500842]. - featured in "back cover picture" [link]
• Arai, T.; Moribatake T.; Masu H. Chiral Bis(imidazolidine)-derived NCN Pincer Rh Complex for Catalytic Asymmetric Mannich Reaction of Malononitrile with N-Boc Imines. Chem. Eur. J. 2015, 21, 10671-10675. [DOI: 10.1002/chem.201502097].
• Arai, T.; Tsuchiya, K.; Matsumura E. PyBidine–NiCl2-Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin-Derived Ketimines. Org. Lett. 2015, 17, 2416–2419. [DOI: 10.1021/acs.orglett.5b00928]
• Arai, T.; Ogawa, H.; Awata, A.; Sato, M.; Watabe, M.; Yamanaka, M. PyBidine-Cu(OTf)2-catalyzed asymmetric [3+2] cycloaddition using imino esters: Harmony of Cu-Lewis acid and imidazolidine-NH hydrogen-bonding in concerto catalysis. Angew. Chem. Int. Ed. 2015, 54,1595-1599. [DOI: 10.1002/anie.201410782]
• Arai, T.; Joko, A. Sato K. Design of a Chiral Secondary Amine Ligand for Cu-catalyzed anti-Selective Henry Reaction. Synlett, 2015, 26, 209-214. [DOI: 10.1055/s-0034-1379607]
• Awata, A.; Arai, T. PyBidine/Copper Catalyst: Asymmetric exo′-Selective [3+2] Cycloaddition using Imino Ester and Electrophilic Indole. Angew. Chem. Int. Ed. 2014, 53, 10462-10465 [DOI: 10.1002/anie.201405223] - highlighted in SYNFACTS of the month [jpg]
• Arai, T.; Matsumura, E.; Masu, H. Bis(imidazolidine)pyridine-NiCl2 Catalyst for Nitro-Mannich Reaction of Isatin-Derived N-Boc Ketimines: Asymmetric Synthesis of Chiral 3-Substituted 3-Amino-2-oxindoles. Org. Lett. 2014, 16, 2768-8522. [DOI: 10.1021/ol501085y] - highlighted in SYNFACTS [jpg]
• Arai, T.; Sugiyama, N.; Masu, H.; Kado, S.; Yabe, S.; Yamanaka, M. Trinuclear Zn3(OAc)4-3,3’-bis(aminoimino)binaphthoxide Complex for Highly Efficient Catalytic Asymmetric Iodolactonization. Chem. Comm. 2014, 42, 8287-8290. [DOI: 10.1039/C4CC02415J] - featured in "cover picture" [link]
• Arai, T.; Matsumura, E. Switching Enantioface Selection in the Asymmetric Nitro-Mannich Reaction Using Single Chiral Bis(imidazolidine)pyridine-metal Catalysts. Synlett 2014, 25, 1776-1780. [DOI: 10.1055/s-0034-1378204]
• Arai, T.; Yamamoto, Y. Diversity-Oriented Asymmetric Catalysis (DOAC): Stereochemically Divergent Synthesis of Thiochromanes Using an Imidazoline-Aminophenol-Nickel Catalyzed Michael/Henry Reaction. Org. Lett. 2014, 16, 1700-1703. [DOI: 10.1021/ol500361w] - highlighted in SYNFACTS [jpg]
• Awata, A.; Wasai, M.; Masu, H.; Kado, S.; Arai, T. Imidazoline-aminophenol (IAP)-nickel complex: Structure and catalytic activity in enantioselective 1,4-addition of 3'-indolyl-3-oxindoles to nitroethylene. Chem. Eur. J. 2014, 20, 2470-2477. [DOI: 10.1002/chem.201304456]
• Sato, T.; Arai, T. Chiral Bis(oxazolidine)pyridine-Cu-Catalyzed Enantioselective Friedel-Crafts Alkylation of Indole with Nitroalkenes. Synlett, 2014, 25, 349-354. [DOI: a10.1055/s-0033-1340311] - highlighted in SYNFACTS [jpg]
• Oyama, S.; Fujino, H.; Yamazaki, R.; Okura, I.; Regan, J. W.; Awata, A.; Arai, T.; Murayama, T. Novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells, Archives of Biochemistry and Biophysics. 2014, 541, 21-29. [link]
• Arai, T.; Kajikawa, S.; Matsumura, E. The Role of Ni-carboxylate During Catalytic Asymmetric Iodolactonization Using PyBidine-Ni(OAc)2. Synlett, 2013, 24, 2045-2048.[DOI: 10.1055/s-0033-1339676]
• Arai, T. Catalytic Asymmetric [3+2]-Cycloaddition Reaction for Controlling Multiple Stereogenic Centers on Pyrrolidines. J. Synth. Org. Chem, Japan. 2013, 71, 672-682.
• Arai, T.; Ogino, Y.; Sato, T. Developmet of a Tailor-made Bis(oxazolidine)pyridine-metal Catalyst for the [3+2] Cycloaddition of Azomethine Imines with Propiolates. Chem. Commun. 2013, 49, 7776-7778.[DOI: 10.1039/C3CC44354J] - featured in "inside back cover" [link], highlighted in SYNFACTS [jpg]
• Arai, T.; Y. Yamamoto; Awata, A.; Kamiya, K.; Ishibashi, M.; Arai, M. A. Catalytic Asymmetric Synthesis of Mixed 3,3'-Bisindoles and Their Evaluation as Wnt Signaling Inhibitors. Angew. Chem. Int. Ed. 2013, 52, 2486-2490.[DOI: 10.1002/anie201208918] - selected as Hot Paper [Link] and highlighted in SYNFACTS [jpg]
• Arai, T.; Oka, I.; Morihata, T.; Awata, A.; H. Masu. A Neutral, Chiral, Bis(imidazolidine)-derived NCN-type Palladium Pincer Complex Demonstrating Catalyst Activity.Chem. Eur. J. 2013, 19, 1554-1557.[DOI: 10.1002/chem.201204017] - Most Accessed Articles: January 2013[link]
• Awata, A.; Arai, T. Catalytic Asymmetric Cyclopropanation with Diazooxindole. Synlett, 2013, 24, 29-32.[DOI: 10.1055/s-0032-1317746]-highlighted in SYNFACTS [jpg]
• Arai, T.; Mishiro, A.; Matsumura, E.; Awata, A.; Shirasugi, M. syn-Selective Asymmetric Mannich Reaction of Sulfonyl Imines with Iminoesters Catalyzed by the N,N,N-Tridentate PyBidine-Cu(OTf)2 Complex. Chem. Eur. J. 2012, 18, 11219-11222.[DOI: 10.1002/chem.201201537]
• Awata, A.; Arai, T. Catalytic Asymmetric Exo'-selective [3+2] Cycloaddition for Constructing Stereochemically Diversified Spiro[pyrrolidin-3,3'-oxindoles. Chem. Eur. J.2012, 18, 8278-8282.[DOI: 10.1002/chem.201201249]
• Arai, T.; Ogino, Y. Chiral Bis(Imidazolidine)Pyridine-Cu Complex-Catalyzed Enantioselective [3+2]-Cycloaddition of Azomethine Imines with Propiolates. Molecules, 2012, 17, 6170-6178.[DOI: 10.3390/molecules17056170]
• Arai, T.; Kawasaki, N.; Kanoh, H. Magnetically Separable Cu-carboxylate MOF Catalyst for Henry Reaction. Synlett. 2012, 1549-1553.[DOI: 10.1055/s-0031-1290935]
• Arai, T.; Sakagami, K. Asymmetric Banzoylation of meso-Hydrobenzoin Using a Reusable Tripodal Imidazoline-Pyridine-Cu Catalyst. Eur. J. Org. Chem. 2012, 1097-1100.[DOI: 10.1002/ejoc.201101722]
• Arai, T.; Awata, A.; Wasai, M.; Yokoyama, N.; Masu, H. Catalytic Asymmetric Friedel-Crafts/Protonation of Nitroalkenes and N-Heteroaromatics. J. Org. Chem. 2011, 76, 5450-5456. [DOI: 10.1021/jo200546a]-highlighted in SYNFACTS [pdf]
• Arai, T.; Wasai, M.; Yokoyama, N. Easy Access to Fully Functionalized Chiral Tetrahydro-β-Carboline Alkaloids. J. Org. Chem. 2011, 76, 2909-2912. [DOI: 10.1021/jo1025833]
• Arai, T.; Yokoyama, N.; Mishiro, A.; Sato, H. Catalytic Asymmetric Exo'-Selective [3+2] Cycloaddition of Iminoesters with Nitroalkenes. Angew. Chem. Int. Ed. 2010, 49, 7895-7898. [DOI: 10.1002/anie.201004098]- highlighted as SYNFACTS of the Months [pdf]
• Arai, T.; Taneda, Y.; Endo,Y. Formation of Multi-stereogenic Centers Using a Catalytic Aymmetric Henry Reaction. Chem. Commun. 2010, 46, 7936-7938. [DOI: 10.1039/C0CC03022H]
• Arai, T.; Ikematsu, Y.; Suemitsu, Y. Nickel-catalyzed multicomponent coupling reaction using ynones. Pure Appl. Chem. 2010, 82, 1485-1490. [DOI: 10.1351/PAC-CON-09-09-08]
• Arai, T.; Mishiro, A.; Yokoyama, N.; Suzuki, K.; Sato, H. Chiral Bis(imidazolidine)pyridine-Cu(OTf)2: Catalytic Asymmetric Endo-Selective [3+2] Cycloaddition of Imino Esters with Nitroalkenes. J. Am. Chem. Soc. 2010, 132, 5338-5339. [DOI: 10.1021/ja100265j]
• Arai, T. Solid-phase Catalysis/CD-HTS: A Powerful Technology Platform for Exploring Novel Asymmetric Catalysts. J. Synth. Org. Chem., Jpn, 2010, 68, 19-32.
• Arai, T.; Suzuki, K. Design and Synthesis of Chiral Imidazolidine-Pyridine Ligands. Synlett 2009, 3167-3170.[DOI: 10.1055/s-0029-1218311]
• Yanagisawa, A.; Satou, T.; Izumiseki, A.; Tanaka, Y.; Miyagi, M.; Arai, T.; Yoshida, K. Methanol-Assisted Catalysis by Chiral Tin Methoxides: An Alternative Asymmetric Aldol Process. Chem. Eur. J. 2009, 15, 11450-11453.[DOI: 10.1002/chem.200901822]
• Yokoyama, N.; Arai, T. Asymmetric Friedel-Crafts reaction of N-heteocycles and nitroalkenes catalyzed by imidazoline-aminophenol-Cu complex. Chem. Commun. 2009, 3285-3287.[DOI: 10.1039/b904275j]-highlighted in SYNFACTS [pdf]
• Yanqagisawa, A.; Matsumoto, T.; Arai, T.; Yoshida, K. Dibutyltin Dibromide-catalyzed Trimethylsilylcayanation of Aldehydes and Imines. Chem. Lett. 2009, 38, 336-337.[DOI: 10.1246/cl.2009.336]
• Takizawa, S.; Arai, T.; Sasai, H. Development of Novel Immobilization Methods for Multicomponent Asymmetric Catalyst (MAC). J. Synth. Org. Chem., Jpn, 2009, 67, 194-207.
• Arai, T.; Suemitsu, Y.; Ikematsu, Y. Ni(0)-Catalyzed Conjugate Addition of Me3SiCN to Ynones: α-Bromo-β-cyano Tetrasubstituted Enones. Org. Lett. 2009, 11, 333-335.[DOI: 10.1021/ol802508q]
• Arai, T.; Mizukami, T.; Mishiro, A.; Yanagisawa, A. Kinetic Resolution of 1,2-Diols Using Nitrogen-Tethered Bisimidazoline-Copper(I) Catalyzed Benzoylation. Heterocycles, 2008, 76, 995-1000.[abstract]
• Yanagisawa, A.; Izumi, Y.; Arai, T. Michael Addition Reaction of Alkenyl Trichloroacetates Catalyzed by Dibutyltin Dimethoxide. Chem. Lett. 2008, 37, 1092-1093. [DOI: 10.1246/cl.2008.1092]
• Yanagisawa, A.; Suzuki, T.; Koide, T.; Okitsu, S.; Arai, T. Selective Propargylation of Carbonyl Compounds and Imines with Barium Reagents. Chem. Asian J. 2008, 3, 1793-1800. [DOI:10.1002/asia.200800264]
• Arai, T.; Yokoyama, N. Tandem Catalytic Asymmetric Friedel-Crafts/Henry Reaction: Acyclic Three Contiguous Stereocenters. Angew. Chem. Int. Ed. 2008, 47, 4989-4992.[DOI: 10.1002/anie.200801373]-selected as Hot Paper & highlighted in SYNFACTS[pdf]
• Arai, T.; Takashita, R.; Endo, Y.; Watanabe, M. Yanagisawa, A. Aymmetric syn-Selective Henry Reaction Catalyzed by Sulfonyldiamine-CuCl-Pyridine System. J. Org. Chem.2008, 73, 4903-4906. [DOI: 10.1021/jo800412x]-highlighted in SYNFACTS [pdf]
• Arai, T.; Yokoyama, N.; Yanagisawa, A. A Library of Chiral Imidazoline-Aminophenols: Discovering an Efficient Reaction Sphere. Chem. Eur. J. 2008, 14, 2052-2059.[DOI: 10.1002/chem.200701439]
• Yanagisawa, A.; Arai, T. Recent advances in chiral phosphine-silver(I) complex-catalyzed asymmetric reactions. Chem. Commun. 2008, 1165-1172. [DOI: 10.1039/b717104h]
• Arai, T.; Sato, T.; Kanoh, H.; Kaneko, K.; Oguma, K.; Yanagisawa, A. Organic-Inorganic Hybrid Polymer-Encapsulated Magnetic Nanobeads Catalysts. Chem. Eur. J. 2008, 14, 882-885.[DOI:10.1002/chem.200701371]-highlighted in SYNFACTS[pdf]
• Arai, T.; Watanabe, M.; Yanagisawa, A. Practical Asymmetric Henry Reaction Catalyzed by a Chiral Diamine-Cu(OAc)2 Complex. Org. Lett. 2007, 9, 3595-3597. [DOI: 10.1021/ol7014362]
• Miura, T.; Natsume, S.; Kanemoto, K.; Atsumi, K.; Fushimi, H.; Sasai, H.; Arai, T.; Yoshida, T.; Ajito, K. Novel Azalides Derived from Sixteen-Membered Macrolides. J. Antibiot. 2007, 60, 407-435.
• Yanagisawa A.; Takahashi, H.; Arai, T. One-pot synthesis of 1,5-diketones by barium isopropoxide. Tetrahedron, 2007, 63, 8581-8585.
• Arai, T.; Mizukami, T.; Yanagisawa, A. Reaction Optimization Using Solid Catalysis-CD HTS: Nb-Imidazoline-Cu(I) Catalyzed Asymmetric Benzoylation of meso-1,2-Diols. Org. Lett. 2007, 9, 1145-1147. [DOI: 10.1021/ol0702122]
• Arai, T.; Endo, Y.; Yanagisawa, A. Salicylhydrazone ligands for enantioselective addition of diethylzinc to aldehydes Tetrahedron: Asymmetry 2007, 18, 165-169.[DOI:10.1016/j.tetasy.2007.01.022]
• Yanagisawa, A.; Shinohara, A.; Takahashi, H.; Arai, T. Barium Hydride Promoted Homocoupling and Cross-Coupling Reactions of Enones: An Alternative Entry to Diels-Alder Adducts. Synlett, 2007, 141-145.
• Yanagisawa, A.; Ichikawa, T.; Arai, T. Dibutyltin Dimethoxide and BINAP•Silver(I) Complex-catalyzed Asymmetric Aldol Reaction of Alkenyl Trichloroacetates with Aldehydes. J. Orgnomet. Chem. 2007, 550-553.
• Takahashi, H.; Arai, T.; Yanagiswa, A. 1,5-Diketone Synthesis Promoted by Barium Hydride or Barium Alkoxides. Synlett, 2006, 2833-2835.
• Arai, T.; Sato, T.; Kanoh, H.; Kaneko, K.; Yanagisawa A. Direct α-Hydroxylation of Ketones Catalyzed by Organic-Inorganic Hybrid Polymer. Chem. Lett. 2006, 35, 1094-1095.
• Yanagisawa, A.; Aoki, T.; Arai, T. Dibutyltin Oxide-Catalyzed Allyl Transfer Reaction to Aldehydes. Synlett, 2006, 2071-2074.
• Arai, T.; Watanabe, M.; Fujiwara, A.; Yokoyama, N.; Yanagisawa, A. Direct Monitoring of Asymmetric Induction of Solid Phase Catalysis Using Circular Dichroism: Diamine-Cu(I) Catalyzed Asymmetric Henry Reaction. Angew. Chem. Int. Ed. 2006, 45, 5978-5981.-highlighted in SYNFACTS[pdf]
• Jayaprakash, D.; Takizawa, S.; Arai, T.; Sasai, H. Development of efficient methods for the immobilization of multicomponent asymmetric catalysts. Journal of Experimental Nanoscience, 2006, 1, 477-510.
• Yanagisawa, A.; Touge, T.; Arai, T. Asymmetric protonation of silyl enolates catalyzed by chiral phosphine-silver(I) complexes. Pure and Applied Chemistry, 2006, 78, 519-523.
• Mitsuhashi, K.; Ito, R.; Arai, T.; Yanagisawa, A. Catalytic Asymmetric Protonation of Lithium Enolates Using Amino Acid Derivatives as Chiral Proton Sources. Org. Lett. 2006, 8, 1721-1724.
• Arai, T.; Fujiwara, A.; Watanabe, M.; Yokoyama, N.; Fujito, T.; Deguchi, K.; Yanagisawa A. Quality Control of Solid-Phase Synthesis: 13C PST/MAS NMR Analysis on Non-destructed SynPhase Lantern. Tetrahedron Lett. 2006, 47, 1673-1677.
• Arai, T.; Takasugi, H.; Sato, T.; Noguchi, H.; Kanoh, H.; Kaneko, K.; Yanagisawa A. Catalytic Synthesis of α-Hydroxy Ketones Using Organic-Inorganic Hybrid Polymer. Chem. Lett. 2005, 34, 1590-1591.
• Yanagisawa, A.; Saito, H.; Harada, M.; Arai, T. Mannich-Type Reaction Using Alkenyl Trichloroacetates Catalyzed by Dibutyltin Dimethoxide. Adv. Synth. Catal., 2005, 347, 1517-1522.
• Arai, T.; Mizukami, T.; Yokoyama, N.; Nakazato, D.; Yanagisawa, A. Design and Synthesis of a Chiral N-tethered Bis(imidazoline) Ligand. Synlett, 2005, 2670-2672.
• Yanagisawa, A.; Okitsu, S.; Arai, T. Regioselective Propargylation of Carbonyl Compounds with (3-Bromo-prop-1-ynyl)trimethylsilane Promoted by Reactive Barium. Synlett, 2005, 1679-1682.
• Yanagisawa, A.; Touge, T.; Arai, T. Enantioselective Protonation of Silyl Enolates Catalyzed by BINAP-AgF Complex. Angew. Chem. Int. Ed. 2005, 44, 1546-1548.
• Kim, Y-K.; Arai, M. A.; Arai, T.; Lamenzo, J. O.; Dean III, E. F.; Patterson, P. A.; Clemons, P. A.; Schreiber, S. L. Relationship of Stereochemical and Skeletal Diversity to Cellular Measurement Space. J. Am. Chem. Soc. 2004, 126, 14740-14745.
• Yanagisawa, A.; Goudu, R.; Arai, T. Selective Synthesis of α,β-Unsaturated Ketones by Dibutyltin Dimethoxide-catalyzed Condensation of Aldehydes with Alkenyl Trichloroacetates. Org. Lett., 2004, 6, 4281-4283.
• Yanagisawa, A.; Nakamura, Y.; Arai, T. α-Amino Acid-promoted Asymmetric Allylation of Aldehydes with Allylstannanes. Tetrahedron: Asymmetry, 2004,15, 1909-1913.
• Yanagisawa, A.; Takahashi, H.; Arai, T. Reactive Barium-promoted Reformatsky-type Reaction of α-Chloroketones with Aldehydes. Chem. Commun. 2004, 580-581.
• Arai, M.; Shinohara, T.; Arai, T.; Sasai, H. Development of the First Spiro Bis(isoxazoline) Ligands (SPRIXs) and Their Applications to Catalytic Enantioselective Reactions. J. Synth. Org. Chem, Japan. 2004, 62, 61-69